Abstract
AbstractPurpose The objective of the study was to evaluate wheather an assessment of conjunctival epithelium expression of HLA‐DR and ICAM‐1 could be helpful as an early marker of local inflamation in the eye and the orbital tissue.Methods Specimens for flow‐cytometric evaluations of ICAM‐I and HLADR expression were collected by impression of ocular surface from 8 eyes with Graves’ diaseas without signs of active Graves’ orbitopathy (CAS ≤ 4), from 8 eyes of patients with active Graves’ orbitopathy (CAS ≥ 4) and from 14 normal speciments without any ocular surface disorders.Results Decreased fluorescence of ICAM‐1 on conjunctival epithelium cells was detected in patients with active Graves orbitopathy vs. patients with Graves wihout orbitopathy. There was no correlation between the CAS and NOSPECS values and the expression of ICAM‐I and HLADR expression on conjuctival epithelium.Conclusion Results of this preliminary study confirm that conjunctival epithelial cells may abnormally express ICAM‐1 on conjunctival epithelium cells in active ocular surface disorder like Graves orbitopathy. Nethertheless, since the number of the examined patients needs to be enlarged the study needs further examination.
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