IC-P2-096: Risk factors for dementia in the epidemiological study of Munguialde County

Abstract

AD group had a trend towards a higher brain atrophy rate than MCI (p 0.052). Ventricular enlargement was different between the three groups (p 0.001), with AD MCI (p 0.001), AD control (p 0.001) and MCI control (p 0.001). Change in MMSE was also different between controls, MCI and AD (p 0.001), with AD MCI (p 0.009) and AD controls (p 0.001) (table). In both MCI and AD groups change in MMSE was associated with BBSI (MCI p 0.001, AD p 0.003) and VBSI (MCI p 0.001, AD p 0.001). Finally, the MCI group was divided into two groups: those with MMSE change 1, and MMSE change or equal to 1. There was no significant interaction between BBSI and MMSE change in the MCI divisions (p 0.05), but there was a significant interaction between MMSE change and VBSI and MCI divisions (p 0.01), (Figure). Conclusions: Whole-brain atrophy rates and ventricular enlargement increased across subject groups with control MCI AD. This was also reflected in neuropsychology, with MMSE change increasing across groups control MCI AD. Some association was found between MMSE (change) and brain atrophy and ventricular enlargement in AD and MCI.