Abstract
EBM2 BACKGROUND AND PURPOSE: The hippocampus is a widely recognized area of early change in AD, yet voxelwise analyses of FDG-PET activity differences between AD and CN controls have consistently failed to identify hippocampal hypometabolism. In this article, we propose a high-dimensional PETspecific analysis framework to determine whether important hippocampal metabolic FDG-PET activity differences between patients with AD and CN subjects are embedded in the Jacobian information generated during spatial normalization.
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Schedule a callMore From: Alzheimer's & Dementia: The Journal of the Alzheimer's Association
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