Ibuzole: A Thwart for NSAID's Causing Gastro-Duodenal Endoscopic Ulcer

Abstract

The oral route of Drug delivery is considered most perfect and patient complied of drug administration. Non-Steroidal anti-inflammatory Drugs (NSAID) are most widely and frequently prescribed for their anti- inflammatory, anti-thrombotic, anti-pyretic and analgesic activity. NSAID’s are given through oral route, but also at same time NSAID’s are most common factor causing Gastro-duodenal Endoscopic Ulcer. Ibuprofen is used mainly for treatment of orthopaedic disease. It has well known potential to generate gastritis and peptic ulcer by both local and systemic action. Omeprazole is proton pump inhibitor use for treatment of peptic ulcer. Aim of our study is to combine NSAID (Ibuprofen) with side effect reducing agent (Omeprazole) and to develop multi component Drug delivery system to increase patient compliance and duration of action and also the cost-effective formulation. This will give effects of NSAID and counteract peptic or duodenal ulcer. Ibuprofen and omeprazole are formulated as a Bilayer tablet for their respective effects. Bilayer tablets have some advantages over the conventional monolayer tablets. hence increasing the patient compliance as well as increasing drugs acceptance by avoiding the side effect. Bilayer tablets have enabled the development of controlled delivery of active pharmaceutical ingredients with predetermined release profiles by combining layers with various release patterns, or by combining slow release with immediate-release layers, hence increasing the patient compliance as well as increasing drugs acceptance by avoiding the side effect.