Abstract
Synthetic biodegradable polymers are considered to be a highly suitable materials for the targeted drug delivery devices creating. Especially promising is the use of the electrospinning technique, which makes it possible to obtain materials with a high surface-to-volume ratio that provides active diffusion of the drug into the body tissues. In order to control the rate of polymer degradation and drug release from polymer scaffolds surface modification techniques are widely used. This study was focused on the investigation of ibuprofen-loaded poly (ε-caprolactone) electrospun fibrous scaffolds and modification of theirs surface. Scaffolds with two ibuprofen concentrations were obtained: 5 wt./wt. % and 10 wt./wt.%. The modification was conducted by the pulsed electron beam irradiation. The sustained release of the model drug over a period of one day from both non-treated and treated samples was demonstrated. It was shown, that treatment leads to an increase in drug release rate and does not change surface morphology of scaffolds and fibers diameter distribution.
Highlights
Biodegradable polymers are widely used in medicine as a means of targeted delivery and controlled release of drugs, as well as materials for regenerative medicine
There are no significant changes in surface morphology of scaffolds and fibers diameter distribution after the e-beam irradiation
3) The average molecular weight of polymer in the scaffold decreases with ibuprofen loading
Summary
Biodegradable polymers are widely used in medicine as a means of targeted delivery and controlled release of drugs, as well as materials for regenerative medicine. Modern technologies for medical products and devices formation allow to obtain objects that can simultaneously work both as an extracellular matrix for the new tissues growth and as a means of local drug release. This combination is needed especially for perioperative diseases prevention, what is crucial in military regions, places with poor hygiene and healthcare system. Hetrick et al summarized current trends on designing new polymeric drug release systems for implant-related infections control and showed benefits of incorporating antibiotics into a polymeric coat for implants [1]
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