Abstract
139 patients due to undergo surgery for the removal of an impacted third molar were enrolled in a multicentre, randomised, double-blind, double-dummy, placebo-controlled study to compare the efficacy and tolerability of a new formulation of the nonsteroidal anti-inflammatory drug (NSAID) ibuprofen, ibuprofen arginine, with those of naproxen sodium in the prophylaxis of pain. Each drug was administered as a single oral dose 15 minutes before surgery. Postoperative pain intensity was assessed on a Visual Analogue Scale (VAS) at fixed time-points after surgery, and patients completed a global assessment of efficacy at the end of the study.
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