Abstract
Background: To determine the iatrogenic risk factors for cytomegalovirus (CMV) retinitis in patients with the acquired immunodeficiency syndrome (AIDS). Methods: The case-control study included 120 patients with CMV retinitis and 159 patients without CMV retinitis, all of whom had AIDS and CD4 counts less than 50 cells/μL at the time of diagnosis of retinitis or at the defined corresponding date in the controls. Iatrogenic risk factors studied were corticosteroid use, treatment with chemotherapy, treatment with radiotherapy, and blood transfusions. Results: Among the risk factors studied, only steroid use was predictive of CMV retinitis (odds ratio 6.41,95% confidence interval 2.35–17.51). Based on this study, the use of steroids systemically elevated the risk of CMV retinitis. Interpretation: This result may be useful to clinicians and health policy specialists in developing rational guidelines for screening, examination frequency, and targeted prophylaxis for patients with AIDS.
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Schedule a callMore From: Canadian Journal of Ophthalmology/Journal canadien d'ophtalmologie
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