Iatrogenic Angiomatous Kaposi's Sarcoma of the Gingiva in a Patient with Small Lymphocytic Lymphoma/Chronic Lymphocytic Leukemia

Abstract

IATROGENIC ANGIOMATOUS KAPOSI’S SARCOMA OF THE GINGIVA IN A PATIENT WITH SMALL LYMPHOCYTIC LYMPHOMA/CHRONIC LYMPHOCYTIC LEUKEMIA Sulen Sarioglu, Sermin Ozkal, Guray Akturk, Ersoy Dogan, Mehmet Arici, Fatih Demirkan, Dokuz Eylul University, Faculty of Medicine, Department of Pathology, Izmir, Turkey; Dokuz Eylul University, Faculty of Medicine, Department of Otorhinolaryngology and Head and Neck Surgery, Izmir, Turkey; Dokuz Eylul University, Faculty of Medicine, Department of Hematology, Izmir, Turkey Fifty year old male patient presented with gingival hypertrophic, purple lesion of 4 cm diameter. He had a history of small lymphocytic lymphoma/chronic lymphocytic leukemia with deletion of 13q14.3; diagnosed 9 months ago. He had received fularabine, retoximabe and cyclosporine theraphy was induced and 6 cures could be admitted. Due to low platelet counts biopsy could be performed at the 3rd month. The biopsy revealed surface mucosal ulceration and a submucosal mass of spindle cells and vascular structures filled with blood cells. There was cellular atypia and few atypical mitosis. HHV8, CD31, CD38, D2-40 were positive and ki-67 index was 29%. Final diagnosis was angiomatous type Kaposi sarcoma (KS). The patient was HIV negative. KS of the oral cavity is most frequent in HIV positive patients but, however exceedingly rara, this diagnosis should be kept in mind in patients in cases receiving chemoteraphy for lymphoma.