Abstract
IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, Vol. 17: some N-Nitroso Compounds (1978)
Highlights
This book provides a clear and concise summary of the workshop on Methods in Cancer Research held in Lunteren, The Netherlands, on 24 and 25 April 1978, and is the first of a series on Applied Methods in Oncology
The first part is devoted to the clinical pharmacology of methotrexate, and it is good to see that the important role of "low dose" methotrexate has not been forgotten amidst the current enthusiasm for "high dose" therapy
The discussion following the papers on methotrexate provides further useful information; that following the second half adds little to the book
Summary
This book provides a clear and concise summary of the workshop on Methods in Cancer Research held in Lunteren, The Netherlands, on 24 and 25 April 1978, and is the first of a series on Applied Methods in Oncology. The first part is devoted to the clinical pharmacology of methotrexate, and it is good to see that the important role of "low dose" methotrexate has not been forgotten amidst the current enthusiasm for "high dose" therapy. There are concise reviews of the current methods of measuring methotrexate in biological fluids and attempts to relate toxicity to clinical and kinetic parameters are well covered.
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