I124] Radiobiological model-based treatment individualisation in radiotherapy

Abstract

Recent advances in cellular and molecular tumour biology, functional imaging and computational simulation have made their contribution towards providing information and tools for radiobiological model-based treatment individualisation in radiotherapy. This lecture will give an overview of the current trends in radiobiological modelling accounting for the tumour microenviroment, intrinsic radiosensitivity and density of clonogenic cells that could be used for treatment individualisation and adaptation. The radiobiological models will be placed in the broader context of the clinical applications addressing therefore the treatment approaches for treatment individualisation starting from gathering tumour specimens through biopsies and assessing them for the ability to grow in vitro and form colonies in order to determine their inherent radiosensitivity measured as the surviving fraction at 2 Gy based on clonogenic assay as well as their potential doubling time. The role of functional imaging in providing information regarding the modulation of the radiobiological parameters responsible for the response to treatment of individual patients will also be addressed. Finally, the radiomics signature including radiobiological features will also be discussed.