脳血管障害における血中リポ蛋白異常に関する研究(I)

Abstract

Abnormality in lipoproteins was studied in patients with cerebrovascular disease at the time when more than one month has elapsed after onset. All patients were classified into three groups, cerebral thrombosis, cerebral embolism, and cerebral bleeding, according to the symptoms, history, cerebral angiography and CT.1) Serum apo A-I levels decreased and apo B levels increased in patient with cerebrovascular disease as compaired with control group. When apo B/A-I ratio was examined, it increased more remarkably in patients with cerebrovascular disease, and therefore is a good atherogenic marker in cerebrovascular disease.2) Total cholesterol levels was not altered, but TG levels increased in patients with cerebrovascular disease compaired with control group.3) In LDL fraction, cholesterol content did not change, but apo B increased in patients with cerebrovascular disease as compaired with control group. The chol/Apo B ratio in LDL fraction decreased in cerebrovascular disease, indicating apo B rich LDL being more atherogenic.4) Serum oxidized lipoprotein levels increased in cerebral thrombosis and embolism, but not in cerebral bleeding. Further analysis has revealed that, in LDL fraction, oxidized LDL increased in all three groups.These results suggest that qualitical abnormality in lipoproteins, especially apo B rich and oxidized LDL, have important roles in the outbreak and progression of cerebrovascular disease.