Abstract
AbstractWe report a chemoselective tandem oxidative cyclization/aromatization of indole derivatives tethered to aniline sulfonamides using catalytic amount of tetrabutylammonium iodide in the presence of tert‐butyl hydroperoxide (TBHP) as an oxidant under nearly neutral conditions at room temperature. The corresponding indolo[2,3‐b]quinolines were obtained as sulfonate salts, which could be easily isolated in analytically pure form via only a simple filtration of the crude reaction mixture. The natural product quinindoline could be easily obtained after basic work‐up of the sulfonate salt. Control experiments revealed that both ionic and radical active species could be generated in situ under mild conditions for the corresponding oxidative transformations to proceed in a chemoselective manner.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
