Abstract
Chronic obstructive pulmonary disease (COPD) is a global chronic disease of the respiratory system. The formation of pathological changes in the lungs is primarily associated with the impact of harmful chemicals of the tobacco smoke on the epithelium of the respiratory tract. In addition to the activation of key COPD processes, an important role in the development of the disease played by genetic determinants and disruption of epigenetic regulation, including changes in DNA methylation, histone modification, and microRNA expression. The article discusses the genetic and epigenetic aspects of COPD as a heterogeneous disease with a complex pathogenesis.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: BULLETIN of L.N. Gumilyov Eurasian National University. BIOSCIENCE Series
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
