Hystochrome influence on physical endurance of rats

Abstract

Introduction. Domestic antioxidant drugs series «Gistohrom®» are based on the marine natural compounds echinochrome A. «Gistohrom®»activates cell energy metabolism and protein synthesis, increases the body’s endurance under extreme physical exertion. The aim of the research was to study effect of different «Gistohrom®» doses on the physical endurance rats. Material and Methods The male Wistar rats were ranked into three groups: group 1 (n = 17) and group 2 (n = 15) for 10 days subcutaneously treated «Gistohrom®» on doses 1 mg/kg and 10 mg/kg, respectively, while the control group (n = 20) received the same quantity of saline injections. Physical endurance (efficiency) was evaluated by the test swim. Results Repeated exposure to extreme physical exertion accompanied by increased efficiency in all groups of animals. In the control group of rats swimming duration increased to 9,31 ± 0,39 min (p < 0,001) and reached maximum values at the 9th day of the experiment. Physical endurance in rats exceeded by 1,7 times comparison reference values when «Gistohrom®» administered at a dose of 10 mg/kg, and by 2,7 times at a 1 mg/kg drug dose. Maximum growth endurance was recorded at 25,59 ± 3,87 minutes after the cancellation of «Gistohrom®» applied in a dose of 10 mg/kg, and at 28,24 ± 4,23 minutes after its administration at a dose of 1 mg/kg. Conclusion . The increase of the time water retention in the control rats group, appears to be the result of long-term adaptation to physical exercise. Increase physical endurance in rats with long-term administration «Gistohrom®» inversely proportional to the administered dose. Perhaps the key mechanism is to modulate the p53 gene activity by echinochrome A.