Hysteroscopic Subendometrial PRP Injection in Cases of Infertility

Abstract

Study Objective To determine the efficacy of Hysteroscopic subendometrial Platelet Rich Plasma (PRP) injection in improving endometrial thickness and pregnancy rates in IVF cases. Design Case-control Study. Setting Patients had hysteroscopy under general anaesthesia or office settings according to their preference, in the dorsal lithotomy position. Patients or Participants 51 patients with history of recurrent IVF failure or thin endometrium ( Interventions Hysteroscopic subendometrial injection of autologous PRP using a wallace needle through the hysteroscope's operating channel to inject the PRP beneath the superficial endometrium in novel technique. Measurements and Main Results Endometrial thickness was measured sequentially post-operative and pregnancy rates following embryo transfer recorded. Conclusion PRP injection significantly improves endometrial thickness and more studies are needed to ascertain pregnancy rates and live birth rates.