Abstract
The pathogenesis of diabetic complications is related to many factors, including genetic susceptibility, glycometabolism disorder,oxidative stress and so on. But the pathogenesis is not so clear. Recent researches show that diabetic complications are closely related to hypoxia,and hypoxia-inducible factor-1 ( HIF-1 ) is an important factor for transcriptional control. HIF-1 participates in angiogenesis, energy metabolism, apoptosis and so on, through controlling the downstream transcription of genes in order to adapt hypoxia environment. Discussing the structure ,function adjustment and effect in diabetic complication of HIF-1, studying how to maintain moderate expression of HIF-1 ,can provide a new method for prevention of diabetic complications. Key words: Diabetic complication; Hypoxia-inducible factor-1; Oxidative stress
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