Abstract
BackgroundSonodynamic therapy (SDT) is an emerging non-invasive therapeutic technique. SDT-based cancer therapy strategies are presently underway, and it may be perceived as a promising approach to improve the efficiency of anti-cancer treatment. In this work, multifunctional theranostic nanoparticles (NPs) were synthesized for synergistic starvation therapy and SDT by loading glucose oxidase (GOx, termed G) and 5,10,15,20-tetrakis (4-chlorophenyl) porphyrin) Cl (T (p-Cl) PPMnCl, termed PMnC) in Poly (lactic-co-glycolic) acid (PLGA) NPs (designated as MG@P NPs).ResultsOn account of the peroxidase-like activity of PMnC, MG@P NPs can catalyze hydrogen peroxide (H2O2) in tumor regions to produce oxygen (O2), thus enhancing synergistic therapeutic effects by accelerating the decomposition of glucose and promoting the production of cytotoxic singlet oxygen (1O2) induced by ultrasound (US) irradiation. Furthermore, the NPs can also serve as excellent photoacoustic (PA)/magnetic resonance (MR) imaging contrast agents, effectuating imaging-guided cancer treatment.ConclusionMultifunctional MG@P NPs can effectuate the synergistic amplification effect of cancer starvation therapy and SDT by hypoxia modulation, and act as contrast agents to enhance MR/PA dual-modal imaging. Consequently, MG@P NPs might be a promising nano-platform for highly efficient cancer theranostics.Graphical
Highlights
Sonodynamic therapy (SDT) is an emerging non-invasive therapeutic technique
The areaelemental mapping analysis of the NPs revealed the existence of Mn element, illustrating the successful loading of PMnC in MG@P NPs (Additional file 1: Figure S1)
The MG@P NPs which labeled with DiI in Poly (lactic-co-glycolic) acid (PLGA) shell exhibited strong red florescence, as detected by confocal laser scanning microscopy (CLSM) (Fig. 1e)
Summary
Sonodynamic therapy (SDT) is an emerging non-invasive therapeutic technique. SDT-based cancer therapy strategies are presently underway, and it may be perceived as a promising approach to improve the efficiency of anti-cancer treatment. It is in pressing need to explore efficient and non-invasive therapeutic modalities for cancer treatments. Even in the presence of normal O 2 levels, cancer cells generally produce energy through anaerobic glycolysis (the Warburg effect), which enhances the cellular sensitivity to changes in intracellular glucose concentration [7, 9]. Given this feature of cancer cells, GOx, which can effectively oxidize glucose into gluconic acid and hydrogen peroxide (H2O2), has gained attention in cancer starvation therapy [10,11,12,13].
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
