Hypoxia Inducible Factor1α in Correlation with Preeclampsia

Abstract

Objective: To know the correlation between Hypoxia Inducible Factor
 (HIF)-1α level with preeclampsia.
 Method: The study was conducted at the Obstetrics and Gynecology
 Department of Prof. Dr. R. D. Kandou Hospital. This research was
 carried out from April to June 2014. This study is a cross-sectional
 analytic approach in preeclampsia and normotensive pregnancy. We
 perform cubital venous blood sampling for inspection by 5 ml of serum
 and stored it in a refrigerator (-20°C). The level of HIF-1α serum
 was done by quantitative ELISA method in Prodia Lab Jakarta.
 Result: Seventy six pregnant women with 38 normotensive pregnancies
 and 38 preeclampsia, showed a significant association between
 the average levels of HIF-1α in the serum of pregnant women
 with preeclampsia compared to normotensive pregnancies (p =
 0.000).
 Conclusion: There is a positive relationship between the levels of
 HIF-1α in serum of preeclampsia, in which HIF-1α levels in preeclampsia
 was higher than normotensive pregnancies.
 [Indones J Obstet Gynecol 2016; 1: 19-22]
 Keywords: hypoxia inducible factor-1α, preeclampsia