Abstract
At the start of pregnancy, trophoblasts (TBs) migrate and invade into the decidua and remodel the spiral arteries in physiologic hypoxic conditions (1-3% O2). Persistent hypoxia secondary to a defect in remodeling of the maternal arteries is proposed to lead to a failure to increase oxygen tension, leading to poor placental perfusion and pregnancy complications, such as preeclampsia (PE). The objectives of this study are to determine how exposure to hypoxia impacts gene expression and cellular motility of first trimester TBs, and to assess if expression of migration-associated genes is dysregulated in 2nd trimester chorionic villous samples (CVS) from PE pregnancies relative to CVS from healthy pregnancies.
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