Abstract
2313 PURPOSE: We investigated the expression of myosin heavy chain-beta (MHC-β) related to the cAMP concentration in both right ventricle (RV) and left ventricle (LV) in rats exposed to moderate hypobaric hypoxic condition for 4 weeks, which allows the comparison between the LV, exposed to hypoxia and the RV, which is additionally subjected to pressure overload which leads to RV hypertrophy. METHODS: Twelve male Wistar-Kyoto rats, 14 weeks old, were randomly assigned to two groups: sealevel control group (CO) and hypoxia group (HX). The CO group was housed 4 weeks at 1,011 hPa while the HX group was housed for 4 weeks at 701 hPa. RESULTS: Hypoxia-induced RV hypertrophy was associated with a significant increase in the MHC-β expression (p<0.05). As well, in non-hypertrophied LVs, the MHC-β expression was significantly increased in the HX group as compared to the CO group (p<0.01). Oxidative enzymatic activities were not changed in both ventricles following 4 weeks of hypoxia. There were no changes in the adenylyl cyclase activities and the phosphodiesterase activities in both ventricles between the CO and the HX group. CONCLUSIONS: These results suggest that the cardiac MHC-β isoform expression was up-regulated by hypoxia per se without a contribution of second messenger cAMP.
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