Abstract
Hypoxia in prostate cancer
Highlights
Dear Editor, I have read with great interest the review “Current challenges and opportunities in treating hypoxic prostate tumors” by McKenna et al.[1]
When reviewing the biological role of hypoxia in malignant tumors, authors lacking an expertise in respiratory physiology often convert - without any need - the in vivo pO values, originally measured in tumors using pO histography[2], into O concentrations using either Dalton’s law or Henry’s law for gases dissolved in solutions, which cannot describe the relationship between partial pressures and concentrations of gases in heterogeneous media
It is strongly suggested to avoid any conversion of measured pO values into cO data since the O solubility coefficient is: (1) highly dependent on the tissue water content; and (2) usually not known for heterogeneous cancer tissues in patients
Summary
Dear Editor, I have read with great interest the review “Current challenges and opportunities in treating hypoxic prostate tumors” by McKenna et al.[1].
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