Abstract
Purpose: We previously showed that acidic leucine-rich nuclear phosphoprotein-32A (ANP32A) plays a key protective role in osteoarthritis (OA) by preventing oxidative stress. In OA cartilage, ANP32A is downregulated as compared to non-OA cartilage. Thus, maintaining or increasing ANP32A levels may protect against OA. Yet, factors regulating ANP32A expression remain unknown. Here, we aim to uncover these regulators in order to identify mechanisms that can be targeted to promote ANP32A expression in the articular cartilage.
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