Abstract
Hypoxia in the tumor microenvironment induces radioresistance in cancer cells, which reduces the treatment efficiency of radiotherapy. Therefore, it is critical to produce sufficient oxygen to alleviate hypoxia to enhance the effect of ionizing radiation. Here, we constructed nanorod-shaped PdTe nanoenzymes to overcome hypoxia and promote the effects of thermoradiotherapy. Both palladium and tellurium are high-Z elements, which interacted with X-rays to generate more DNA radicals in the tumor regions. Moreover, PdTe nanoenzyme could catalyze the conversion of intratumoral overexpressed H2O2 to oxygen, alleviating hypoxia in the tumor regions. Photothermal therapy mediated by PdTe nanoenzymes not only ablated tumors but also accelerated the blood flow, in turn, modulating hypoxia. With good biocompatibility, PdTe nanoenzyme exhibited remarkable oxygen generation ability both in vitro and in vivo, indicating potential ability for radiosensitization. Further investigation using MBT-2 cells and MBT-2 tumor-bearing mice demonstrated that PdTe nanoenzyme could effectively enhance the treatment efficiency of radiotherapy. Thus, our work presented a novel nanoenzyme to overcome hypoxia in tumors for effective thermoradiotherapy.
Highlights
The clinical treatment of cancer involves radiotherapy as a conventional method, which is conducted either alone or in combination with other therapeutic methods (Laprise-Pelletier et al, 2018; Zhu et al, 2020b; Sasieni and Sawyer 2021; Sung et al, 2021; Zheng et al, 2021)
The result of X-ray diffraction (XRD) pattern, consistent with the result of X-ray photoelectron spectroscopy (XPS), in Supplementary Figure S2 suggested that NR was consisted of Pd (JSPDS file 87–0637), TeO2 (JSPDS file 46–1211) and Te (JSPDS file 79–0736)
We evaluated the potential of NR as a nanoenzyme for H2O2, which was overexpressed in the tumor site
Summary
The clinical treatment of cancer involves radiotherapy as a conventional method, which is conducted either alone or in combination with other therapeutic methods (Laprise-Pelletier et al, 2018; Zhu et al, 2020b; Sasieni and Sawyer 2021; Sung et al, 2021; Zheng et al, 2021). This nanorod could catalyze the conversion of intracellular overexpressed H2O2 in tumor regions to O2, which alleviated hypoxia and hereby enhanced the effect of radiotherapy. We investigated in vivo photothermal conversion effect on MBT-2 tumor-bearing mice.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
