Abstract
COVID.19 pandemic alter the people activities worldwide from education, economy to the social and even politic life, as a result of the huge influence of this bio-crisis, extensive research done about this viral infection ,successes produce vaccines to this viral infection within short time. However, harmful consequences flow injection of certain types of this vaccines observed worldwide, ranging from mild symptoms as fever and pain at site of injection to the death. Estradiol constituent of those types of vaccine play an important role coagulation problem (thromboembolism) flowed receiving of it. Suitable precautions must be considered before administering this types of vaccine.
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