Abstract
OPINION article Front. Mol. Neurosci., 30 December 2013Sec. Neuroplasticity and Development Volume 6 - 2013 | https://doi.org/10.3389/fnmol.2013.00055
Highlights
From work carried out largely by Alain Prochiantz and his co-workers at the College de France (Sugiyama et al, 2008; Beurdeley et al, 2012; Carlier et al, 2013; Smythies and Edelstein, 2013; Spatazza et al, 2013a,b), it is known that the homeoprotein and transcription factor molecule Otx2 possesses a very unusual property
THE REST OF THE JOURNEY Here we present three hypotheses
Sugiyama et al (2008) have shown that it can cross the plasma membrane of the target PV-expressing GABAergic INs (PVs), since cortical infusion over 5 days results in robust Otx2 signaling throughout the visual cortex
Summary
From work carried out largely by Alain Prochiantz and his co-workers at the College de France (Sugiyama et al, 2008; Beurdeley et al, 2012; Carlier et al, 2013; Smythies and Edelstein, 2013; Spatazza et al, 2013a,b), it is known that the homeoprotein and transcription factor molecule Otx2 possesses a very unusual property. Otx2 would use one of these axonal transport mechanisms during its travel along axons, as it is difficult to visualize it wriggling on its own along axons from one cell to the for these long distances. Sugiyama et al (2008) have shown that it can cross the plasma membrane of the target PVs, since cortical infusion over 5 days results in robust Otx2 signaling throughout the visual cortex.
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