Hypothermia treatment reduced cyclin-dependent kinase 5-mediated inflammation in ischemic stroke and improved outcomes in ischemic stroke patients

Sombat Muengtaweepongsa,Winchana Srivilaithon

doi:10.6061/clinics/2020/e1992

Abstract

Dear Editor, We read with interest the article by Sun et al. concerning the reduction of inflammation with therapeutic hypothermia in acute ischemic stroke (). In this study, the authors demonstrated the improvement of inflammatory biomarkers after hypothermia treatment in both animal cerebral infarct models and patients with ischemic stroke. […] Hypothermia treatment reduced cyclin-dependent kinase 5-mediated inflammation in ischemic stroke and improved outcomes in ischemic stroke patients

Highlights

We read with interest the article by Sun et al concerning the reduction of inflammation with therapeutic hypothermia in acute ischemic stroke (1)
Almost all the clinical trials of temperature management (TTM) in ischemic stroke relied on systemic cooling with surface and endovascular methods
These two methods are effective enough to bring down the core temperature to 33oC, which is the target point of the treatment (3)

Summary

Introduction

We read with interest the article by Sun et al concerning the reduction of inflammation with therapeutic hypothermia in acute ischemic stroke (1). Almost all the clinical trials of TTM in ischemic stroke relied on systemic cooling with surface and endovascular methods. These two methods are effective enough to bring down the core temperature to 33oC, which is the target point of the treatment (3).

Results

Conclusion