Abstract
Gastric ulceration in rats had been demonstrated as an effect of physical restraint. The etiology remains undetermined. Evidence is presented that hypothermia plays an important role in the process. Appropriately restrained rats, whether single or parabiosed, develop macroscopic ulcerations and show a significant drop in body temperature during restraint. Unrestrained rats that develop ulcers as a result of parabiosis to restrained rats show similar drops in temperature. Body temperatures of unrestrained parabionts that failed to develop macroscopic ulcers returned to control values after declining slightly during the first third of the restraint period.
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