Abstract
In our previous paper, we reported that spontaneous hypothermia (HT) during ischemia protects against delayed neuronal death in the hippocampus but not against acute brain edema following transient forebrain ischemia, which is induced by occlusion of the bilateral common carotid arteries (BCCA) in C57BL/6J mice. We here demonstrate that artificial HT after reperfusion (rHT) suppresses the aggravation of acute brai ne dema in the BCCA occlusion C57BL/6J mouse model. Ourresults suggest that mechanisms regulated by rHT are involved in the attenuation of acute brain edema after reperfusion in this model of cerebral ischemia.
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