Hypothalamic, Proline-Rich Polypeptide (Galarmin) has Protective and Immunogenic Activity on Experimental Mycobacterium Tuberculosis Infection

Abstract

The effects of hypothalamic, proline-rich polypeptide (PRP) on experimental Mycobacterium tuberculosis infection in mice were investigated. Female, pathogen-free C57BL/6 strains of mice aged 2–4 months of age and synthetic analogue of PRP in doses of 1 µg/mice for 24 hours before infection of Mycobacterium tuberculosis H37 Rv Pasteur were used for the experiments. PRP enhanced the survival of mice infected in lethal doses. PRP had a pronounced protective effect during the period of development of the infections. It was established that PRP reduced the growth of mycobacteria in the internal organs of infected mice. The duration of the persistence of the microorganisms in the body was reduced after the use of PRP, and the elimination of bacteria from the body was enhanced. PRP has prophylactic and therapeutic effects on Mycobacterium tuberculosis infection. PRP also enhances the effectiveness of preventive and therapeutic vaccinations with BCG, and may be used for creation of new generation vaccines against pulmonary tuberculosis.