Hypothalamic digoxin and pathophysiology of migraine

Abstract

The study investigated hypothalamic digoxin secretion and dysregulation of the isoprenoid pathway in migraine and the role of hemispheric dominance in the genesis of migraine. The isoprenoid pathway, tryptophan / tyrosine catabolic patterns, glycoconjugate metabolism, red blood cell membrane composition and lipid peroxidation parameters were assessed in people with classical migraine and in people with right hemispheric dominance, left hemispheric dominance and bihemispheric dominance. The results showed that the isoprenoid pathway was upregulated with increased digoxin synthesis in patients with migraine. There was an increase in tryptophan catabolites and a decrease in tyrosine catabolites. The dolichol and glycoconjugate levels were increased and lysosomal stability was decreased in migraine. The ubiquinone levels were low and free radical levels were increased. The cholesterol : phospholipid ratio was increased and the amount of glycoconjugate was reduced in the blood cell membrane of patients with migraine. This pattern in migraine correlated with that of right hemispheric dominance. Hypothalamic digoxin and right hemispheric chemical dominance play key roles in the genesis of migraine.