Hypotensive mechanism of acetyl glyceryl ether phosphorylcholine (AGEPC) in dogs. effects on hemodynamics and humoral factors

Abstract

One-O-hexadecyl-2-O-acetyl- sn -glycero-3-phosphorylcholine (AGEPC) was intravenously administered to anesthetized dogs to study the effects on hemodynamics and several endocrine factors. The effect of AGEPC on local blood flow was also studied by direct intraarterial injection. Following intravenous injection, blood pressure and cardiac output decreased significantly (p < 0.001). Changes in total peripheral resistance (TPR) and heart rate were biphasic. TPR increased significantly (p < 0.01) after an initial slight reduction. Heart rate decreased significantly (p < 0.01) with only a transient slight elevation. Femoral blood flow was increased (p < 0.001) by intraarterial injection and decreased (p < 0.05) by intraveneous administration. Plasma norepinephrine (p < 0.001), epinephrine (p < 0.01), thromboxane B 2 (p < 0.001),6-0-PGF 1α (p < 0.01), aldosterone (p < 0.001) and cortisol (p < 0.001) were elevated, but plasma renin activity did not change. These results suggest that the hypotensive mechanism of AGEPC is due to both cardiosuppression and vasodilation: AGEPC increased plasma catecholamines, thromboxane A 2, PGI 2, aldosterone and cortisol which, in turn, may modify hemodynamics.