Abstract
Nucleotides can modify intraocular pressure (IOP). We have tested the ability of uridine-5′-diphosphate, UDP, for modulating IOP in New Zealand white rabbits. Uridine 5′ diphosphate, UDP, reduced IOP by 82.9 ± 2.6% compared to control. Dose-response analysis demonstrated a concentration dependent pattern which presented a pD 2 value of 7.57 ± 1.45, equivalent to an EC 50 of 26.91 nM. Of all the tested P2 receptor antagonists, suramin, pyridoxalphosphate-6-azophenyl-2, 4-disulfonic acid (PPADS) and Reactive Blue 2 (RB-2), only the last two were able to reverse the action triggered by UDP. Altogether, UDP acting probably on P2Y 6 receptors present on the ciliary processes, can reduce intraocular pressure, indicating that this substance may be used for the treatment of ocular hypertension and glaucoma.
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