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Abstract
Intravenous administration of hydro-methanolic extract ofCyperus scarious (3–10 mg/kg) produced hypotensive and bradycardiac effects. These effects remained unaltered in atropinized animals indicating that cardiovascular effects of the plant extract are not mediated through activation of muscarinic receptors. In thein vitro studies, it suppressed the spontaneous contractions of guinea-pig paired atria, rat uterus and rabbit jejunum in a concentration-dependent (0.1–1 mg/ml) manner. It also inhibited histamine or acetylcholine-induced contractions of guinea-pig ileum indicating non-specific spasmolytic action. In rabbit aorta, it inhibited norepinephrine (10 μM) as well as K+ (80 mM)-induced contractions at similar concentrations (0.1–1mg/ml). These data indicate thatCyperus scariosus contains Ca2+ channel blocker-like constituent(s) which may explain hypotensive effect observedin vivo and the general spasmolytic activity of plant may explain its folkloric use in diarrhoea.
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