Abstract
After thyroidectomy, hypertrophy of the pituitary body, with obvious formation of colloid substance has been repeatedly described. In rabbits, Stieda found that nine weeks after the extirpation of the thyroid gland, the weight of the hypophysis had doubled. Also after castration, enlargement of this organ has been observed in man, the rabbit and in birds. Exceptions have, however, been reported. Hans Kühn came to the conclusion that castration is of no influence on the dimensions and the weight of the pituitary body in horses (Dissertation, Bern, 1910). Pathological enlargement of the hypophysis can take rise in three different ways: (1) originating from rests of the hypophysis vesicle, (2) originating from the ependyma of the infundibular canal, (3) by hyperplasia of the glandular part. Rests of the hypophysis vesicle are often met with in quite normal hypophyses as small cysts, lined with epithelium. These occur regularly in ruminants, pigs and carnivores, but not in horses. When they can be demonstrated
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