Abstract
BackgroundTo investigate the prognostic value of hyponatremia, defined as serum sodium level < 135 mEq/L, in radiation-induced brain necrosis (RN) patients.MethodsWe performed a retrospective analysis of the RN patients (The patients included in our study had a history of primary cancers including nasopharyngeal carcinoma/glioma/oral cancer and received radiotherapy previously and then were diagnosed with RN) treated in Sun yat-sen Memorial Hospital from January 2013 to August 2015. Patients without cranial magnetic resonance imaging (MRI) scan and serum sodium data were excluded. Progression was identified when the increase of edema area ≥ 25% on the MRI taken in six months comparing with those taken at the baseline. Factors that might associate with prognosis of RN were collected. Multivariable logistic regression analyses were used to identify potential predictors.ResultsWe total included 135 patients, 32 (23.7%) of them with hyponatremia and 36 (26.7%) with RN progression. Percentage of progression was roughly three fold in hyponatremia patients compared with nonhyponatremia patients (53.1% versus 18.4%), translating into a 5-fold increased odds ratio (P < 0.001). Multivariable analyses identified hyponatremia as a potential predictor of progression (OR, 4.82; 95% CI [1.94–11.94]; P = 0.001).ConclusionsHyponatremia was identified as a potential predictor for the progression of patients with RN. Hyponatremia management in patients with RN should be paid much more concern in clinical practice.
Highlights
To investigate the prognostic value of hyponatremia, defined as serum sodium level < 135 mEq/L, in radiation-induced brain necrosis (RN) patients
Documentaries suggest that hyponatremia probably serves as an onlooker reflecting the severity of diseases since it might be preexisting [6, 15, 16], which might be induced by cerebral salt wasting syndrome(CWS) and the syndrome
We retrospectively collected the data of patients diagnosed with RN (The patients included in our study had a history of primary cancers including nasopharyngeal carcinoma/glioma/oral cancer and received radiotherapy previously and were diagnosed with RN) and treated at Department of Neurology, Sun Yat-Sen Memorial Hospital from January, 2013 to August, 2015
Summary
To investigate the prognostic value of hyponatremia, defined as serum sodium level < 135 mEq/L, in radiation-induced brain necrosis (RN) patients. There is consistent evidence demonstrating that hyponatremia acts as risk factors in various diseases such as cancer [4] and heart failure [5], and has close relationship with central nervous system (CNS) diseases, such as stroke [6], subarachnoid hemorrhage [7, 8] and meningitis [9, 10], through inducing longer hospital stay, increased mortality, and raised complications [11,12,13,14]. Documentaries suggest that hyponatremia probably serves as an onlooker reflecting the severity of diseases since it might be preexisting [6, 15, 16], which might be induced by cerebral salt wasting syndrome(CWS) and the syndrome
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