Abstract
Community acquired pneumonia is one the frequent cause of hospital admissions. Whereas, hyponatremia is a common electrolyte abnormality in hospitalized patients and has been shown to be associated with considerable morbidity and mortality. We aim to studyt the association of hyponatremia with community acquired pneumonia in terms of morbidity and mortality. A prospective observational hospital based study was conducted in a hospital for a year. All patients with a diagnosis of community acquired pneumonia and admitted in medicine ward, were included. Patients with diarrhea, known Chronic Kidney Disease, Heart Failure, Cirrhosis of Liver, Malignancy, taking diuretics, chemical pneumonitis, interstitial pneumonias and other debilitating disease were excluded. Among the 72 cases of CAP, 61% were females and 39% were males. The mean age of patients was 51.3 years, 22 (30.55%) patients had severe CAP. A total of 7 cases expired with an overall mortality of 13.7%. The mortality risk increased with increasing CURB-65 score; CURB-65 score 0, 0%; CURB-65 score 1, 0%; CURB-65 score 2, 0%; CURB-65 score 3, 10%; CURB-65 score 4, 33%; CURB-65 score 5, 100%. i.e higher the CURB-65 score, higher the death rate of CAP patients (p<0.05). Hyponatremia was a common occurrence at hospital admission with an incidence of 36.11%. Hyponatremia at hospital admission was also associated with a longer length of hospital stay in cured CAP patients. The mean length of hospital stay was 4.3 days. High CURB-65 scores and lower values of serum sodium at admission in patients of CAP are associated with adverse outcomes both in terms of mortality and longer length of hospital stay. CURB-65 score should be incorporated into assessment of CAP and sodium of the patients during admission.
Highlights
IntroductionHyponatremia is a common electrolyte abnormality in hospitalized patients and has been shown to be associated with considerable morbidity and mortality
Community acquired pneumonia is one the frequent cause of hospital admissions
It is estimated that Nepal, India, Bangladesh and Indonesia account for 40% of global acute respiratory infections; 90% mortality is due to pneumonia mostly bacterial in origin.[3]
Summary
Hyponatremia is a common electrolyte abnormality in hospitalized patients and has been shown to be associated with considerable morbidity and mortality. We aim to studyt the association of hyponatremia with community acquired pneumonia in terms of morbidity and mortality. Community acquired pneumonia (CAP) is a common disorder with an incidence of about 20-30% in developing countries and 3-4% in developed countries[1] and potentially serious illness associated with considerable morbidity and mortality in elderly patients with significant comorbidities.[2] It is estimated that Nepal, India, Bangladesh and Indonesia account for 40% of global acute respiratory infections; 90% mortality is due to pneumonia mostly bacterial in origin.[3]. Karki et al Clinical Evaluation of Fused/Ankylosed Hip with Severe Flexion Deformity after Conversion to Total Hip Arthroplasty site-of-care decisions.[4] hyponatremia occurs in 15-30% of hospitalized patients.[5] Hyponatremia has clearly been shown to be a common electrolyte abnormality in pneumonia. The aim of the study was to determine the relation of hyponatremia in patients admitted with community acquired pneumonia
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