Abstract
Hyponatremia is a frequent problem in chronic liver disease. To the best of our knowledge, no study of hyponatremia in chronic liver disease has been conducted in our setting. The aim of this study is to study the prevalence of hyponatremia in patients with chronic liver disease attending the outpatient department of a tertiary care hospital. This descriptive cross-sectional study was conducted in 114 patients with chronic liver disease attending the out-patient department of a tertiary care hospital in Kathmandu, Nepal between November 2020 and July 2021. Ethical approval was taken from the Institutional Review Committee of Nepal Medical College and Teaching Hospital (Reference number: 028-077/078). Convenience sampling was done. The collected data was entered and analyzed in Microsoft Excel. Calculation of point estimate at 95% confidence interval was done along with frequency and proportion for binary data. Among 114 patients with chronic liver disease studied, 47 (41.22%) (32.18-50.25 at 95% Confidence Interval) patients had hyponatremia (≤130mmol/L) with mean age of 53.44±7.57 years. Thirty (63.8%) patients out of these were males and 17 (36.2%) patients were females. The prevalence of hyponatremia among patients with chronic liver disease was found to be higher when compared to other similar studies.
Highlights
Hyponatremia is a frequent problem in chronic liver disease
The aim of this study is to study the prevalence of hyponatremia in patients with chronic liver disease attending the outpatient department of a tertiary care hospital
Hyponatremia in chronic liver disease is a condition characterised by increased renal retention of water relative to sodium because of impairment in the clearance of solute-free water, which is frequent in individuals with cirrhosis and portal hypertension.[1]
Summary
Hyponatremia is a frequent problem in chronic liver disease. To the best of our knowledge, no study of hyponatremia in chronic liver disease has been conducted in our setting. The aim of this study is to study the prevalence of hyponatremia in patients with chronic liver disease attending the outpatient department of a tertiary care hospital. Hyponatremia is common in patients with advanced stages of liver diseases. Patients with chronic liver disease (CLD) may develop hyponatremia due to either hypovolemia or hypervolemia. Studies have shown that the severity of the hyponatremia is related to the severity of the chronic liver disease.[2,3,4] Nepal’s data on the occurrence of hyponatremia in chronic liver disease are scarce.[5] To the best of our knowledge, no study of hyponatremia in chronic liver disease has been conducted in our setting
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