Hypolipidemic Effects of High Hydrostatic Pressure Extract of Ginger in Rats Fed a High‐fat Diet

Abstract

This study compared the hypolipidemic effect of hot water extract of ginger(WEG) and high hydrostatic pressure extract of ginger (HPG) in rats fed with a high‐fat diet. Male Sprague‐Dawley rats were divided into four groups and fed a normal diet (NOR), a high‐fat diet (HFD), a high‐fat diet supplemented with 0.8% WEG (WEG) and a high‐fat diet supplemented with 0.8% HPG (HPG) for 10 weeks. HPG supplementation significantly reduced body weight and epididymal adipose tissue weight compared to HFD group (p<0.05). In the WEG group, the body weight and epididymal adipose tissue weight tended to be lowered compared to those of HFD group. Rats supplemented with HPG showed lower serum triglyceride (TG) and higher serum HDL level compared to those of HFD group (p<0.05). Additionally, HPG significantly decreased the levels of hepatic total lipids, TG and total cholesterol (TC), while fecal total lipids, TG and TC were significantly increased compared to HFD group (p<0.05). These results suggest that HPG more efficiently reduced than WEG the body weight and improved lipid profiles through decreasing hepatic lipids and promoting fecal lipids excretion.Support or Funding InformationThis work was supported by the Brain Korea 21 plus project funding (No. 22A20130012143)