Abstract
The fermentation of food materials with suitable probiotic strains is an effective way to improve biological activities. In this study, seaweed extracts were fermented by Saccharomyces cerevisiae and Lactiplantibacillus plantarum, and the hypolipidemic effects of the fermentation products were investigated. In vitro experiments suggested that fermented seaweed extracts have a high capacity for bile acid-binding. Additionally, a significant inhibitory effect against pancreatic lipase was observed. Furthermore, effects in hyperlipidemic mice were determined. Fermented seaweed extracts can alleviate lipid metabolism disorder. The administration of fermented seaweed extracts to mice showed decreased total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C) levels and increased high-density lipoprotein cholesterol (HDL-C) levels. Combined, these results suggest that fermented seaweed extracts perform a potent hypolipidemic action, thus providing an effective method for the preparation of functional foods to combat cardiovascular diseases.
Highlights
Hyperlipidemia is considered a disorder of lipid metabolism, including increased levels of total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C), with decreased levels of high-density lipoprotein cholesterol (HDL-C; Deng et al, 2019)
Several studies aimed to understand the interactions between S. cerevisiae and L. plantarum (Alexandre, 2004; Russo et al, 2020)
Few references have been reported about the interactions between S. cerevisiae and L. plantarum for seaweed fermentation
Summary
Hyperlipidemia is considered a disorder of lipid metabolism, including increased levels of total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C), with decreased levels of high-density lipoprotein cholesterol (HDL-C; Deng et al, 2019). Due to the side effects of drug treatments for hyperlipidemia, more attention should be paid to dietary supplements to lower blood lipids. L. japonica is rich in polysaccharides, Hypolipidemic Effects of Fermented Seaweed polyphenols, carotenoids, dietary fiber, vitamins, and minerals, and many of the compounds have been reported to exhibit a variety of biological activities (Kadam and Prabhasankar, 2010). To obtain these bioactive molecules, various methods have been applied, including acid base hydrolysis, solvent extraction, and enzymatic digestion (Tan and Lee, 2015; García-Vaquero et al, 2018). The bioactive compounds in L. japonica were exposed, and more importantly, the bioactivities of fermented seaweed extracts were shown to have been enhanced (Papanna et al, 2012; Kuda et al, 2015; Suraiya et al, 2018)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
