Abstract
Hypolipidemic effects of dandelion (Taraxacum officinale) extracts were investigated in C57BL/6 mice fed atherogenic diet for 6 weeks. Control, DWE (I and II) (1.5 and 3% dandelion water extract) and DEE (I and II) (1.5 and 3% dandelion ethanol extract) groups were used. Plasma triglyceride (TG), total cholesterol, and low density lipoprotein (LDL) cholesterol levels and the atherogenic index of dandelion groups were significantly (p<0.05) reduced, compared to controls. Hepatic total lipids, TG, and cholesterol levels were significantly (p<0.05) decreased in DEE groups, while the cholesterol level was significantly (p<0.05) decreased in DWE II group, compared to controls. Fecal lipid excretion was significantly (p<0.05) increased in DEE groups. Expression of hepatic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase was significantly (p<0.05) down-regulated in DWE groups and up-regulated in DEE groups, compared to controls. DWE and DEE exert a hypolipidemic effect via decreased HMG CoA reductase expression and increased fecal lipid excretion.
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