Abstract
The goal of the extant revision was to explore the influence of caffeic acid (CA) extracted from Arctium lappa L. on lipid profile and histology of aorta in rats . Analytical study demonstrated a high percentage of both chlorogenic and caffeic acid in the 80 % methanol extract of the aerial parts (leaves and stems) of Arctium lappa L. from the family Asteraceace. Hypolipidemic activity of caffeic acid was studied against cholesterol induced hypercholesterolemia in Wistar albino rats for thirty days. Rats were separated into normal group (A), hypercholesterolemic positive controller group (B). While, the rest three groups (C, D and E) attended as hypercholesterolemic trial groups. Caffeic acid was given verbally at doses of 20 mg / kg body mass in Collection (C), 40 mg/kg in Collection(D) then 20 mg/ kg in collection (E) after two weeks of administration of cholesterol induced hypercholesterolemia. There was an obvious histological improvement of changes induced by hypercholesteremia in aorta. Furthermore, using (CA) at 20mg after 2 weeks of feeding on cholesterol rich diet led to a important decline (P<0.05) in serum whole cholesterol levels in compassion with the control and cholesterol rich diet group. Moreover, There was a great improvement in the histology results convinced by the high cholesterol gorgeous diet, which can partly be attributed to an antioxidant activity of (CA). 
 Keywards: Arctium lappa, Caffeic acid , Hypolipidimic, Hypercholesterolemia.
Highlights
The goal of the extant revision was to explore the influence of caffeic acid (CA) extracted from Arctium lappa L. on lipid profile and histology of aorta in rats
The results In table -1- of groups given diet rich with cholesterol and treated with 20 and 40mg/kg of caffiec acid could be attributed to the activity of CA in decreasing serum total cholesterol levels in rats, in addition to any organic anion that competes with acetate can reduce the input of acetyl CoA and block the first step in cholesterol synthesis and Benzalbutyric acid impairs cholesterol and fatty acids synthesis by blocking acetylation of coenzyme A, The similarity in chemical structure of CA with βBenzylbutyric acid may suggest similar mechanism of action, this result agreement with result reported by Bowman and Rand [17]
Many investigational and scientific studies are established the atherosclerosis and circumstances disposing to atherosclerosis like hypercholesterolemia, increase in pressure and patient with great smoke are related with augmented vascular creation of radical oxygen species [18]
Summary
The goal of the extant revision was to explore the influence of caffeic acid (CA) extracted from Arctium lappa L. on lipid profile and histology of aorta in rats. Group (C): Rats were given 20mg/kg/day of caffeic acid besides high cholesterol diet.
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