Abstract
In this study, the hepatoprotective and hypolipidemic effects of high-polydextrose snack food on Swiss albino mice were investigated. The mice were randomly divided into three groups: control diet, high-fat diet, and high-fat and fiber diet groups. Addition of high-polydextrose snack to the high-fat diet resulted in significant reduction in the liver weight, the accumulation of lipid droplets in liver, and the liver damage of hyperlipidemic mice in comparison with the high-fat diet. The high-polydextrose snack also decreased the content of total triglyceride, cholesterol, and low-density lipoprotein cholesterol as well as the alanine aminotransferase and aspartate aminotransferase activities in the mice serum. In addition, the high-polydextrose snack significantly increased the high-density lipoprotein cholesterol content of the hyperlipidemic mice. Consequently, use of high-polydextrose snack generated hepatoprotective and hypolipidemic effects on hyperlipidemic mice.
Highlights
Public awareness on health and food safety has been increased, and the concept of a fiber-rich diet is gaining great importance due to digestive health benefits [1]
Dietary fiber deficiencies in human nutrition are related with several diseases such as colon cancers, constipation, cardiovascular diseases, and diverticulosis [2]
It is reported that polydextrose improves the growth of some intestinal bacteria such as Clostridium difficile and Bifidobacterium which provide physiological benefits to human health [4]. e impacts of polydextrose digestion on postprandial insulin and glucose response were investigated in numerous studies
Summary
Public awareness on health and food safety has been increased, and the concept of a fiber-rich diet is gaining great importance due to digestive health benefits [1]. Dietary fiber could reduce energy intake, increase immune system, improve intestinal microbiota activity, and enhance postprandial lipid responses [3]. With a low glycemic index (4–7), polydextrose is proved to decrease the potential of blood glucose level rising in the human body [5]. Polydextrose intake reduces glucose absorption from the small intestine and improves bowel function for health [6]. Various studies have been performed to increase the fiber content of extruded snack food, whereas it is not well known how snack fibers affect health benefit through animal testing. The Journal of Nutrition and Metabolism hyperlipidemia mice model was selected with a high-fiber diet to investigate the possible hypolipidemic and hepatoprotective effects of snack food enriched in polydextrose on hyperlipidemic mice
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