Hypolipidemic and Antioxidant Effect of Garcinia Gummi-Gutta Barkson Atherogenic Diet-Induced Hyperlipidemic Rats

Abstract

Objective: To evaluate the Hypolipidemic& Antioxidant effect of Garcinia gummi-gutta barks on Atherogenic Diet-Induced Hyperlipidemic Rats. Materials and methods: Bark extract was prepared using a Soxhlet apparatus. 30 Wistar albino rats of either sex was divided into 5 groups (n=6). Atherogenic diet (AD) was administered to all the rats except group 1 for 4 weeks. Following induction, Group 3 & 4 were treated with bark extracts at 100 & 200mg/kg respectively and group 5 with atorvastatin at 10mg/kg for the next 4 weeks along with AD. Weekly estimation of lipid profile was done and, in the end, all the animals were sacrificed and the liver and heart were sent for histopathological examination. MDA levels were estimated by measuring the TBARS activity. Results were expressed in the Mean ± standard error of the mean. Statistical analysis was done using one-way ANOVA followed by post hocTukey test. p<0.05 is considered statistically significant. Result: There was a significant decrease in the mean cholesterol, triglyceride, low-density lipoproteins&very-low-density lipoproteins and an increase in High-density lipoproteins when compared to the AD group. Barks extracts at both doses (100mg/kg & 200mg/kg) showed a significant reduction in lipid profile wherein the extract at higher dose was found to be better and there was no significant difference when compared to atorvastatin. Conclusion: The study showed that bark extract of Garcinia gummi-guttapossess significant hypolipidemic & antioxidant activity. Further studies are warranted for its clinical use in humans.