Abstract
This study was performed to evaluate the hypolipidemic and anti‐atherogenic activities of the crude polysaccharides extracted from abalone viscera (AVCP). The major functional groups of purified polysaccharides were analyzed by infrared spectroscopy (IR). Male Kunming mice (SPF) were divided into six groups and were treated with normal diet or high‐fat diet with AVCP or Xuezhikang (hypotensive drug) for 5 weeks. Physicochemnical analysis of AVCP showed the presence of 60.4% polysaccharides, 17.9% protein, 6.0% fat and 10.9% moisture. The IR analysis of AVP showed the presence of functional groups of sugar moiety and sulfate groups. The results demonstrated that AVCP not only led to significant reduction of total cholesterol (TC), triglycerides (TG), low‐density lipoprotein cholesterol (LDL‐C), and increase of high‐density lipoprotein cholesterol (HDL‐C) in plasma, but also to significant increments of malondialdehyde (MDA) and superoxide dismutase (SOD) activities. However, AVCP played no role in mice weight. Furthermore, the results of the photomicrograph of liver tissue showed that AVCP reduced lipid droplets and prevented the disordered structure of the liver. The results suggested that AVCP exhibited significantly hypolipidemic and anti‐atherogenic activities.
Highlights
Abalone (Haliotis discus hannai) is one of the most valuable marine mollusks throughout the world
After 5 weeks, the weights of mice in each group are shown in Figure 5, and it indicated that the various treatment interventions demonstrated no significant difference in the body weight of mice
Effect of abalone viscera polysaccharides (AVCP) on the level of total cholesterol (TC) After 5 weeks fed, the results in Table 5 demonstrated that compared to group C which was treated with high-fat diet and 0.9% saline, the mice in groups A, B, D, E, and F showed significant decreases (p < .01) in TC levels (30.21%, 26.81%, 25.96%, 28.94%, and 29.79%)
Summary
Abalone (Haliotis discus hannai) is one of the most valuable marine mollusks throughout the world. The by-products from the abalone processing, viscera, may account for 15%–25% of the total body weight of raw material (Zhou et al, 2012). This visceral matter is considered as an inedible part and normally discarded as industrial waste, which may pose a disposal problem due to the ease of spoilage and environmental pollution (Zhu et al, 2008). Atorvastatin drugs are widely used to treat atherosclerosis since it can decrease the level of plasma LDL-C and has a strong antioxidant effect. These drugs have adverse effects, such as a headache, abdominal distension, and insomnia (Lusis, 2000), which are harmful to the human body. The objective of the study was to investigate the effect of AVCP on the hypolipidemic and anti-atherogenic activities
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