Abstract
Hyperlipidemia is characterized by increased level of cholesterol in the form of low-density lipoprotein (LDL), chylomicrons, VLDL. Guizotia abyssinica Cass (Ramtil) seeds are one among the sources for the edible oil, which are low in saturated fat, cultivated commonly in Northern part of Karnataka. Materials and Methods: Guizotia abyssinica Cass (Ramtil) seeds were collected authenticated seed oil extracted by Cold compression method. The experiment carried out in Wistar albino rats, inducing Hyperlipidemia by HFD, along with administration of test drugs (Guizotia abyssinica Cass. seed oil Single and double dose) and Standard Atorvastatin. Results & Discussion: G. abyssinica Cass seed oil found to decrease total cholesterol and LDL. Even not showed significant increase in HDL. Protective action over the Liver, Kidney and heart through histopathological study exhibit its safety aspect. Conclusion: G. abyssinica Cass seed oil in HFD induced Hyperlipidemia found effective and safe.
Highlights
Hyperlipidemia is characterized by increased level of cholesterol in the form of low-density lipoprotein (LDL), chylomicrons, VLDL
Guizotia abyssinica Cass (Ramtil) seeds are one among the sources for the edible oil, which are low in saturated fat, cultivated commonly in Northern part of Karnataka
Materials and Methods: Guizotia abyssinica Cass (Ramtil) seeds were collected authenticated seed oil extracted by Cold compression method
Summary
The quest for finding the new safe and effective drug for hyperlipidemia in order to protect against cardiovascular disease is going to be a continuous process amongst the scientific fraternity. (1) Herbs form a source of food, as well as therapeutics when used properly. (2) Everyone looking for plant-based diet rich in fruit, vegetables, legumes with low saturated fat as an effective prescription for Hyperlipidemia. (3) These natural products, apart from lowering fat will provide essential trace elements, nutrition to the body, thereby keep a person disease free and fit. (4) Guizotia abyssinica Cass (Ramtil) seeds are one among the sources for the edible oil seeds cultivated commonly in Northern part of Karnataka and consumed in the form of different dishes like chutney, oil source etc. (5) As per traditional claim these are said to be rich with nutritional factors, various trace elements, good for joint diseases and oil extracted out of these seed is said as a source healthy oil, best in heart diseases, obesity and other problems. (6). The quest for finding the new safe and effective drug for hyperlipidemia in order to protect against cardiovascular disease is going to be a continuous process amongst the scientific fraternity. (3) These natural products, apart from lowering fat will provide essential trace elements, nutrition to the body, thereby keep a person disease free and fit. (5) As per traditional claim these are said to be rich with nutritional factors, various trace elements, good for joint diseases and oil extracted out of these seed is said as a source healthy oil, best in heart diseases, obesity and other problems. (7) Current life style disorders such as diabetes, obesity,. With this background, an experimental study designed to evaluate hypolipidemic activity of Guizotia abyssinica Cass seed oil on Wistar rats
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