Hypoglycemic Potential of the Young Leave Methanolic Extract of Magnifera indica in Alloxan Induced Diabetic Rat

Abstract

2 Abstract: The study was designed to investigate the hypoglycemic potential of Magnifera indica young leave methanolic extract in alloxan induced diabetic rat. Albino rats each weighing 100-200g were given a peritoneal injection of 120mg of Alloxan per kg body weight. After 7 days the blood glucose level of th e animals were checked to ascertain a diabetic state. Those that were diabetic were selected for the study. Oral administration of Magnifera indica leave extract (0.5g/kg body weight) or (1.0g/kg body weight) for 14 days resulted in a significant reduction in blood glucose level from 171.4±4.58 (mg/dl) to 103.7±1.45 (mg/dl) in diabetic rat given 1.0g/kg body weight dose and from 134.2±10.34 (mg/dl) to 97.7±7.01 (mg/dl) in diabetic rat given 0.5g/kg body weight dose, dose dependent being more effective at 1.0g/kg body weight dose than 0.5g/kg body weight dose.