Abstract
Considerable research work has been done to improve insulin preparations in terms of controlled onset and duration of action [l-5] . However, despite the various types of insulin preparations available for therapy, it may still be of some interest to follow new ideas in this field. Thus, based on Katchalski’s work [6] and our own observations with enzymes and other biological active peptides covalentLy linked to synthetic polymers [7], we prepared a water soluble insulin-polyacrylate compound (I-PA).
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