Abstract
Background:Trichosanthes dioica is used to treat diabetes mellitus, epilepsy, alopecia, and skin disease in folklore medicine. The leaf extract of the plant is used in diabetes mellitus but there have been no scientific studies reported.Aims:To study the effect of Trichosanthes dioica on serum glucose level in glucose loaded, normal and hyperglycemic rats.Settings:Kasturba Medical College, Manipal, Karnataka, India.Design:Experimental.Materials and Methods:The aqueous extract of leaves of Trichosanthes dioica are compared with glibeclamide for their influence on fasting blood sugar in glucose loaded, normoglycemic and streptozotocin induced (45 mg/kg ip) hyperglycemic rats.Statistical Analysis:The data was analyzed by one way ANOVA followed by Scheffe's post hoc test.Results:In glucose loaded rats, normal rats and hyperglycemic rats the aqueous extract at both the doses (800 mg/kg/p.o and 1600 mg/kg/p.o) reduced blood glucose significantly when compared to control but it was not as effective as glibenclamide.Conclusion:The aqueous extract of Trichosanthes dioica has antihyperglycemic action.
Highlights
In India, Ayurvedic medicine is reported to have been successfully used in the treatment of diabetes mellitus.[5]As an alternative mode of treatment, Ayurvedic medicine has been claimed to be less toxic and more efficacious
Statistical Analysis: The data was analyzed by one way ANOVA followed by Scheffe’s post hoc test
This study aims to evaluate the antihyperglycemic activity of aqueous extract of leaves of
Summary
In India, Ayurvedic medicine is reported to have been successfully used in the treatment of diabetes mellitus.[5]. As an alternative mode of treatment, Ayurvedic medicine has been claimed to be less toxic and more efficacious. World Health Organization (WHO) Expert committee on Correspondence to Dr K. L. Bairy, Department of Pharmacology, Kasturba Medical College, Manipal - 576 104, India. Trichosanthes dioica is used to treat diabetes mellitus, epilepsy, alopecia, and skin disease in folklore medicine. The leaf extract of the plant is used in diabetes mellitus but there have been no scientific studies reported. Aims: To study the effect of Trichosanthes dioica on serum glucose level in glucose loaded, normal and hyperglycemic rats. Settings: Kasturba Medical College, Manipal, Karnataka, India
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