Abstract
The present study was carried out to investigate the possible antioxidant effects of raisin extract “Karkni” on biochemical parameters in alloxan-induced diabetic rats. Three doses of extract, 125, 250 and 375 mg/kg were orally administered daily to alloxan-diabetic rats for 4 weeks. Alloxan-induced diabetic rats showed significant increases in the levels of blood glucose, triglycerides, cholesterol, low density lipoprotein LDL-cholesterol, creatinine, uric acid, total protein, glycosylated hemoglobin (HbA1c), Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) while high density lipoprotein HDL cholesterol, total hemoglobin and lactate dehydrogenase (LDH) levels were significantly decreased compared to normal rats (P<0.05). The changes of the above parameters to their normal levels after 4 weeks of treatment were observed mainly with the second dose 250 mg/kg. The overall results suggest that the “Karkni” extract possesses potential hypoglycemic and hypolipidemic activity in alloxan-induced diabetic rats.
Highlights
The present study was carried out to investigate the possible antioxidant effects of raisin extract “Karkni” on biochemical parameters in alloxan-induced diabetic rats
Group 1: Non-diabetic untreated rats (Control), Group 2: Diabetic untreated rats, Group 3: Diabetic rats treated with 125 mg/kg “Karkni” extract (D+C1), Group 4: Diabetic rats treated with 250 mg/ kg of the “Karkni” extract (D+C2) and Group 5: Diabetic rats treated
The effects of “Karkni” extract on blood glucose levels in diabetic rats were shown in figure 1
Summary
The present study was carried out to investigate the possible antioxidant effects of raisin extract “Karkni” on biochemical parameters in alloxan-induced diabetic rats. Diabetes is a major degenerative disease in the world today [1], affecting at least 15 million people and having complications which include hypertension, atherosclerosis and microcirculatory disorders [2]. It is associated with long-term complications, including retinopathy, nephropathy, neuropathy and angiopathy [3,4,5]. It was selected to induce diabetes in the present study and the principal objective was to determine the potential beneficial antidiabetic effects of three concentrations of raisin extract (125, 250 and 375 mg/kg) during 4 weeks on alloxan-induced diabetic rats
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