Abstract
<p><strong>Objective: </strong>The aim of the present study was to determine the effects of an olive tree extract with high polyphenols content on blood glucose level and other related parameters in streptozotocin-induced diabetic rats.<strong></strong></p><p><strong>Methods: </strong>Diabetes was induced in rats by intraperitoneal injection of streptozotocin (55 mg/kg bw). 72h after injection, rats with fasting blood glucose higher than 2 g/l were used for the experiments. Olive tree extract was administered for 28 d and blood glucose level was measured every 4 d. Total cholesterol, triglycerides, HDL-cholesterol, creatinine, urea, total protein, uric acid, aspartate aminotransferase and alanine aminotransferase levels, were determined at the end of the experiment.</p><p><strong>Results: </strong>The oral administration of olive tree extract contributes to blood glucose level decreasing in diabetic rats group, which was significantly lower at 4th week compared to the diabetic control rats. Moreover, supplementation by olive tree extract decreased significantly (p&lt;0.05) the values of total cholesterol, triglycerides, HDL-cholesterol, creatinine, urea, total protein, uric acid, aspartate aminotransferase and alanine aminotransferase resulting from damage caused by streptozotocin treatment. Beside this, significant reduce (p&lt;0.05) in heart disease risk ratio was observed for treated group (4.1±0.14) compared to untreated group (7.64±0.36), which was quite similar to normal rats (4.50±0.36). Studied olive tree extract effects were similar to those of glibenclamide, a well-known antidiabetic drug.</p><p><strong>Conclusion: </strong>Results herein obtained reveal the hypoglycemic effect of this olive tree extract, suggesting his potential use as a natural antidiabetic agent.</p>
Highlights
IntroductionDiabetes mellitus is caused by complete or partial deficiencies in insulin production and/or insulin action coupled with chronic hyperglycemia and metabolism disruption [1]
There has been a tragic increase in diabetes mellitus across the world
The results showed that creatinine, urea, and uric acid increased in streptozotocininduced diabetic rats compared with control rats (p
Summary
Diabetes mellitus is caused by complete or partial deficiencies in insulin production and/or insulin action coupled with chronic hyperglycemia and metabolism disruption [1] It is considered as one of the most important clinical risk factors involved in some disorders like nephropathy, retinopathy, neuropathy, and cardiovascular diseases, which its prevalence is predicted to be increased daily [2,3,4,5,6]. There is an increasing demand by patients to use natural products, due to the side effects associated with insulin and oral hypoglycemic agents [8, 9] The study of such products may offer a natural alternative to diabetes management in the future
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
